Microspectrometry-FTIR based glucose and fructose biosensor with pseudo-continuous flow

Hamza Landari; Mourad Roudjane; Younès Messaddeq; Amine Miled

doi:10.1117/12.2545368

21 February 2020 Microspectrometry-FTIR based glucose and fructose biosensor with pseudo-continuous flow

Hamza Landari, Mourad Roudjane, Younès Messaddeq, Amine Miled

Proceedings Volume 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII; 1123509 (2020) https://doi.org/10.1117/12.2545368
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this work, we present a new microspectrometry FTIR-based biosensor for the analysis of sugar based solutions using various solvent and various types of sample handling support (SHS). We used methanol as solvent because it does not interact with infrared (IR) beam. In addition, it ensures a rapid evaporation in order to form a thin layer of targeted molecules on the conventional SHS. The later consists of a total reflective mirror (TRM). Because of methanol toxicity, we developed a new setup for aqueous samples analysis based on accelerated solvent evaporation. The achieved limit of detection (LOD) using the developed biosensor was 3 mM for both, Glucose and Fructose molecules.

Citation Download Citation

Hamza Landari, Mourad Roudjane, Younès Messaddeq, and Amine Miled "Microspectrometry-FTIR based glucose and fructose biosensor with pseudo-continuous flow", Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 1123509 (21 February 2020); https://doi.org/10.1117/12.2545368

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