Simulation and experimental results of a microfluidic dipole designed for brain experiments

Nathaniel Brochu; Hamza Landari; Younes Messaddeq; Amine Miled

doi:10.1117/12.2547267

21 February 2020 Simulation and experimental results of a microfluidic dipole designed for brain experiments

Nathaniel Brochu, Hamza Landari, Younes Messaddeq, Amine Miled

Proceedings Volume 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII; 112350C (2020) https://doi.org/10.1117/12.2547267
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

This paper describes a proof of concept of a microfluidic dipole to sample cerebral fluid. It consists of a portable microfluidic probe which injects a buffer in one inlet and draws it from the other one after passing through a contact zone with the external liquid. Finite elements method modelling (FEM) shows a very stable liquid flow across the complete probing area. Furthermore, we determined that a design generating turbulence is likely to be more useful to capture brain molecules. Molecules displacement due to diffusion phenomena takes about 25 ms to diffuse over a 1 mm probe gap. Finally, our experiment showed that, to obtain a stable flow without turbulence the maximum inlet and outlet pressure is 0.05 mPa for the two tested configuration of dipole.

Citation Download Citation

Nathaniel Brochu, Hamza Landari, Younes Messaddeq, and Amine Miled "Simulation and experimental results of a microfluidic dipole designed for brain experiments", Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 112350C (21 February 2020); https://doi.org/10.1117/12.2547267

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