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24 February 2020 Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism
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Abstract
We present an imaging-based quantitative approach for studying the localized pumping mechanism of the early tubular heart in live mouse embryos. The method relies on 4D (3D+time) imaging of cardiodynamics and hemodynamics of the embryonic heart using structural and Doppler optical coherence tomography (OCT). Our results from the mouse embryo at embryonic day 9.0 (E9.0) show an interesting relationship between the endocardial luminal areas and the localized volumetric blood flows, suggesting that a localized pressure gradient induced by the heart wall movement causes the variation of blood flows, including both the velocity magnitude and flow direction. Data provide new insights into the pumping mechanism of the mammalian tubular heart at the early developmental stage.
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Shang Wang, Riana Syed, and Irina V. Larina "Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390A (24 February 2020); https://doi.org/10.1117/12.2553962
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