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6 March 2020 Iodide-doped gold/silver hybrid nanoparticle for increased sensitivity to reactive oxygen species using photoacoustic imaging (Conference Presentation)
Yash Mantri, Barak Davidi, Jesse V. Jokerst
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Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112401A (2020) https://doi.org/10.1117/12.2546405
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Bacterial infections lead to high oxidative stress due to production of reactive oxygen species like H2O2 and ONOO- inducing cell damage and death. ROS are a short-lived species making direct, precise and real time measurements difficult. Ag+ is a known bactericidal, disrupting metabolism and disulfide bond formation. In this work we synthesized a thernostic nanoparticle that can measure ROS concentrations and release Ag+ in the presence of ROS. The iodide-doped gold/silver hybrid nanoparticle is 10X more sensitive to H2O2 as compared to silver coated gold nanorods.
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Yash Mantri, Barak Davidi, and Jesse V. Jokerst "Iodide-doped gold/silver hybrid nanoparticle for increased sensitivity to reactive oxygen species using photoacoustic imaging (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401A (6 March 2020); https://doi.org/10.1117/12.2546405
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KEYWORDS
Silver
Nanoparticles
Oxygen
Etching
Photoacoustic imaging
Absorption
Coating
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