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17 February 2020 High-speed label-free galvo mirror scanning-based ultraviolet photoacoustic microscopy for histological imaging
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Abstract
Ultraviolet-based photoacoustic microscopy (UV-PAM) has recently been demonstrated as a promising tool to overcome the time-consuming sample preparation procedure in traditional pathological analysis. In order to achieve high-speed UVPAM for clinical usage, we implemented UV-PAM with a single-axis galvo mirror scanner. With our UV laser operating at a repetition rate of 55 kHz, our system produced images ~5.5 times faster than the previously reported point-by-point raster scanning based UV-PAM, with a lateral resolution of ~1.0 μm. Histology-like images of a mouse brain slice were acquired by our system, showing its potential as an intraoperative imaging tool for surgical margin assessment.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Xiufeng Li, Lei Kang, Yan Zhang, and Terence T. W. Wong "High-speed label-free galvo mirror scanning-based ultraviolet photoacoustic microscopy for histological imaging", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401X (17 February 2020); https://doi.org/10.1117/12.2544071
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