Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

Lei Li; Zhiguang Wu; Yiran Yang; Peng Hu; Wei Gao; Lihong V. Wang

doi:10.1117/12.2547559

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17 February 2020 Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

Lei Li, Zhiguang Wu, Yiran Yang, Peng Hu, Wei Gao, Lihong V. Wang

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Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112402R (2020) https://doi.org/10.1117/12.2547559
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo.

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Lei Li, Zhiguang Wu, Yiran Yang, Peng Hu, Wei Gao, and Lihong V. Wang "Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402R (17 February 2020); https://doi.org/10.1117/12.2547559

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