Photoacoustic tomography reconstructing absorption coefficient and effect of regularization minimizing p-norm

Shinpei Okawa; Takeshi Hirasawa; Toshihiro Kushibiki; Masanori Fujita; Miya Ishihara

doi:10.1117/12.2551478

17 February 2020 Photoacoustic tomography reconstructing absorption coefficient and effect of regularization minimizing p-norm

Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Masanori Fujita, Miya Ishihara

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112403N (2020) https://doi.org/10.1117/12.2551478
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Photoacoustic (PA) tomography can be useful to measure the hemoglobin concentration in blood vessels and tissues, and provide important information to determine the course of treatment for hypoxic malignant cancer which possesses the resistance to treatment. To image the hemoglobin concentration and oxygen saturation, the reconstruction of absorption coefficients at multiple wavelengths is required to correct the penetration depths of the multiple wavelengths of light. In this study, the authors tried the image reconstruction of the absorption coefficient for various concentration of photon absorber. Additionally, the effects of the regularizations minimizing 1-norm and p-norm (0<p<1) were compared to examine the improvement of the spatial resolution limited by the characteristics and configurations of the ultrasound transducer and illumination. The PA pressure waves were measured by the probe consisted of the optical fiber and the focused ultrasound transducer. The absorption coefficients of the tubes containing black ink in the phantom made of aqueous solution of Intralipid were from 0.2 to 1.0 mm^-1 at a wavelength of 755 nm, corresponding to the range from normoxic to hypoxic condition of the whole blood. Although the tubes with various absorption coefficients were reconstructed with 1-norm regularization, the tube was reconstructed broadly. On the other hand, the regularization technique minimizing p-norm (0<p<1) localized the tube better than 1-norm regularization. The regularization minimizing p-norm (0<p<1) will improve the spatial resolution of the PA tomography.

Citation Download Citation

Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Masanori Fujita, and Miya Ishihara "Photoacoustic tomography reconstructing absorption coefficient and effect of regularization minimizing p-norm", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112403N (17 February 2020); https://doi.org/10.1117/12.2551478

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available