Photoacoustic microscopy for bone microstructure analysis

John A. Merrill; Siqi Wang; Yue Zhao; Jesus Arellano; Liangzhong Xiang

doi:10.1117/12.2550372

3 March 2020 Photoacoustic microscopy for bone microstructure analysis

John A. Merrill, Siqi Wang, Yue Zhao, Jesus Arellano, Liangzhong Xiang

Proceedings Volume 11241, Biophotonics and Immune Responses XV; 112410H (2020) https://doi.org/10.1117/12.2550372
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Bone disease is a growing epidemic in the world today that will lead to billions of dollars of medical bills. While a range of lifestyle and genetic factors play a role in the progression of disease, in overarching symptom of increased bone porosity leads to decreased mobility, pain, fracture, and even death. Therefore, it is important to monitor trabecular bone for better care of affected individuals. Photoacoustic microscopy (PAM) is a hybrid modality that combines high optical absorption qualities of biological tissue with high spatial resolution of ultrasound. Our study aims to further assess the ability to image bone microarchitecture with photoacoustic imaging. A picosecond-pulsed laser with a wavelength of 532 nm was used to excite the bone while ultrasonic transients were captured by a 20 MHz transducer. We first preformed studies to characterize our lateral resolution and optimize our system using phantoms mimicking different bone porosity. We then imaged pig bone ex-vivo. Our results show that this photoacoustic (PA) imaging has the potential to identify normal and osteoporosis diseased bone. The capability to noninvasively quantify bone tissue composition suggests a possible use of PAM as an optical biopsy for the diagnosis of bone pathologies such as osteoporosis, which are characterized by a progressive reduction and transformation of mineral in the bone matrix.

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John A. Merrill, Siqi Wang, Yue Zhao, Jesus Arellano, and Liangzhong Xiang "Photoacoustic microscopy for bone microstructure analysis", Proc. SPIE 11241, Biophotonics and Immune Responses XV, 112410H (3 March 2020); https://doi.org/10.1117/12.2550372

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KEYWORDS

Bone

Tissue optics

Photoacoustic microscopy

Spatial resolution

Analytical research

Tissues

Transducers

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