Mechanical changes of the crystalline lens in oxidative cataractogenesis assessed with optical coherence elastography

Hongqiu Zhang; Achuth Nair; Salavat R. Aglyamov; Kirill V. Larin

doi:10.1117/12.2548202

25 February 2020 Mechanical changes of the crystalline lens in oxidative cataractogenesis assessed with optical coherence elastography

Hongqiu Zhang, Achuth Nair, Salavat R. Aglyamov, Kirill V. Larin

Author Affiliations +

Proceedings Volume 11242, Optical Elastography and Tissue Biomechanics VII; 112420W (2020) https://doi.org/10.1117/12.2548202
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Age-related cataract is one of the most prevalent causes of visual impairment worldwide. Early detection of cataracts can be immensely helpful for preserving visual acuity by ensuring that the appropriate therapeutic procedures are performed at earlier stages of the disease. In this work, we investigated the relationship between the progression of oxidative cataract and the biomechanical properties of the crystalline lens. We assessed the changes in the stiffness induced by cataracts in porcine lenses in vitro with dynamic optical coherence elastography. The efficacy of α-lipoic acid to minimize the stiffening of the lens was also quantified. The results showed a significant increase in Young’s modulus of the lens due to the formation of the oxidative cataract (from ~ 8 kPa to ~123 kPa). Young’s moduli of the lenses decreased after incubation in α-Lipoic Acid (~123 kPa vs ~45 kPa). These results show that the lens stiffness increased during oxidative cataract formation and that α-lipoic acid has the potential to reduce the stiffening of the lens caused by the oxidative damage.

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Citation Download Citation

Hongqiu Zhang, Achuth Nair, Salavat R. Aglyamov, and Kirill V. Larin "Mechanical changes of the crystalline lens in oxidative cataractogenesis assessed with optical coherence elastography", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 112420W (25 February 2020); https://doi.org/10.1117/12.2548202

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