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9 March 2020 Imaging layered mucosa with visible modulated light (Conference Presentation)
Min Xu, Yang Zheng, Da Pan, Xiafei Qian, Weihao Lin, Bixin Zeng
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Proceedings Volume 11243, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII; 112430M (2020) https://doi.org/10.1117/12.2542976
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Most cancers originate from epithelium, the top layer of mucosa. We report single-snapshot Spatial Frequency Domain Imaging (SFDI) of mucosa with visible modulated light. A novel two-layer mucosa model enables the mapping of the total hemoglobin concentration, the oxygen saturation, the scattering characteristics of the top and bottom layers, and the thickness of the top layer from a single-snapshot. After validating with phantom studies, we demonstrate its applicability to the characterization of mucosa by imaging human mouth lips of healthy subjects. The proposed approach may find important applications in screening mucosa for early detection of cancer and other diseases.
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Min Xu, Yang Zheng, Da Pan, Xiafei Qian, Weihao Lin, and Bixin Zeng "Imaging layered mucosa with visible modulated light (Conference Presentation)", Proc. SPIE 11243, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII, 112430M (9 March 2020); https://doi.org/10.1117/12.2542976
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KEYWORDS
Modulation
Visible radiation
Scattering
Absorption
Cancer
Human subjects
Laser induced plasma spectroscopy
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