High-resolution tissue imaging using moxifloxacin as a clinically compatible cell labeling agent (Conference Presentation)

Ki Hean Kim; Seunghun Lee; Bumju Kim

doi:10.1117/12.2552736

9 March 2020 High-resolution tissue imaging using moxifloxacin as a clinically compatible cell labeling agent (Conference Presentation)

Ki Hean Kim, Seunghun Lee, Bumju Kim

Author Affiliations +

Proceedings Volume 11244, Multiphoton Microscopy in the Biomedical Sciences XX; 112441P (2020) https://doi.org/10.1117/12.2552736
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

High-resolution fluorescence imaging using moxifloxacin as a clinically compatible cell labeling agent is described. Moxifloxacin is an antibiotic with good pharmacokinetic properties for tissue penetration and it has intrinsic fluorescence under ultraviolet (UV) excitation. Alternative usage of moxifloxacin as the cell labeling agent was demonstrated in two-photon tissue imaging of various tissues. Cells within tissues were visualized in enhanced contrasts with moxifloxacin. Moxifloxacin based tissue imaging was explored not only in two-photon excitation but also in both single-photon and three-photon excitations. Moxifloxacin based fluorescence imaging is clinically compatible and has potentials for clinical applications where the cellular examination is needed.

Conference Presentation

Citation Download Citation

Ki Hean Kim, Seunghun Lee, and Bumju Kim "High-resolution tissue imaging using moxifloxacin as a clinically compatible cell labeling agent (Conference Presentation)", Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112441P (9 March 2020); https://doi.org/10.1117/12.2552736

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