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9 March 2020 Multiphoton FLIM is gaining ground as a clinical tool (Conference Presentation)
Hauke Studier, Yousuf S. Mohammed, Michael S. Roberts, Amy Holmes, Michael Pastore, Wolfgang Becker
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Proceedings Volume 11244, Multiphoton Microscopy in the Biomedical Sciences XX; 112441Q (2020) https://doi.org/10.1117/12.2544795
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Multiphoton fluorescence lifetime imaging (FLIM) is gaining ground as a non-invasive and very sensitive method in life sciences, and even as a clinical tool. First clinical devices employing FLIM are on the market, e.g. MPTflex. A hot topic is using metabolic imaging to investigate melanoma lesions (Fig.1). This method utilizes imaging of the ratio of the amounts of the free and protein-bound forms of the intracellular autofluorescent metabolic co-enzyme nicotinamide adenine dinucleotide (NADH) [1,2,3,4]. In another study, we investigated safety aspects of nanoparticle based sun screens. Multiphoton FLIM enables tracing of nanoparticles after application on the skin [5]. Furthermore, in case of penetration into the viable epidermis metabolic imaging can be employed to investigate toxicity on skin cells [6].
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Hauke Studier, Yousuf S. Mohammed, Michael S. Roberts, Amy Holmes, Michael Pastore, and Wolfgang Becker "Multiphoton FLIM is gaining ground as a clinical tool (Conference Presentation)", Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112441Q (9 March 2020); https://doi.org/10.1117/12.2544795
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KEYWORDS
Fluorescence lifetime imaging
Nanoparticles
Skin
Melanoma
Toxicity
Multiphoton fluorescence microscopy
Skin cancer
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