Quantitative phase imaging with epi-mode illumination for fiber-optic endoscopy

Zhe Guang; Patrick B. Ledwig; Paloma Casteleiro Costa; Francisco E. Robles

doi:10.1117/12.2546402

14 February 2020 Quantitative phase imaging with epi-mode illumination for fiber-optic endoscopy

Zhe Guang, Patrick B. Ledwig, Paloma Casteleiro Costa, Francisco E. Robles

Proceedings Volume 11249, Quantitative Phase Imaging VI; 112491T (2020) https://doi.org/10.1117/12.2546402
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Quantitative phase imaging (QPI) provides unique access to cellular and subcellular structures with nanometer-scale sensitivity, making it a valuable tool for non-destructive, label-free imaging of biological samples. However, implementation of QPI typically involves a transmission-based geometry and requires thin samples, preventing use of QPI in many important clinical settings, including endoscopy. In this work we demonstrate a fiber-optic device, with epi-illumination, capable of providing quantitative phase information that is well suited for clinical endoscopy, among other biomedical applications.

Citation Download Citation

Zhe Guang, Patrick B. Ledwig, Paloma Casteleiro Costa, and Francisco E. Robles "Quantitative phase imaging with epi-mode illumination for fiber-optic endoscopy", Proc. SPIE 11249, Quantitative Phase Imaging VI, 112491T (14 February 2020); https://doi.org/10.1117/12.2546402

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available