CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11252 > Article
Presentation
10 March 2020 High-sensitivity impulsive Raman spectroscopy with Doppler Raman spectroscopy (Conference Presentation)
David R. Smith, Jeff J. Field, David G. Winters, Scott R. Domingue, Frauke Rininsland, Daniel J. Kane, Jesse W. Wilson, Randy A. Bartels
Author Affiliations +
Proceedings Volume 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine; 112521Z (2020) https://doi.org/10.1117/12.2546481
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Doppler Raman (DR) spectroscopy is a coherent Raman technique that combines impulsive Raman excitation with novel frequency shift detection to enable high-sensitivity Raman spectroscopy in the biological fingerprint region (500cm-1-1500cm-1) and the low frequency regime from 10cm-1 – 500cm-1. Using DR, we demonstrate nonresonant Raman spectroscopy on a suite of biologically significant targets involved in cell respiration including cytochrome c, adenosine triphosphate (ATP), flavin adenine dinucleotide (FAD), and nicotinamide adenine dinucleotide (NADH). High-sensitivity detection of low-to-medium frequency Raman vibrational modes may provide a tool to monitor states of cell respiration along with large molecular structural changes such as protein conformational dynamics.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
David R. Smith, Jeff J. Field, David G. Winters, Scott R. Domingue, Frauke Rininsland, Daniel J. Kane, Jesse W. Wilson, and Randy A. Bartels "High-sensitivity impulsive Raman spectroscopy with Doppler Raman spectroscopy (Conference Presentation)", Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112521Z (10 March 2020); https://doi.org/10.1117/12.2546481
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Raman spectroscopy
Doppler effect
Imaging spectroscopy
Imaging systems
Proteins
Spectroscopy
Modulation
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top