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3 June 2020 Label-free neurophotonics: electro-plasmonic biosensors for ultrasensitive detection of electrogenic activity of cells (Conference Presentation)
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Proceedings Volume 11257, Plasmonics in Biology and Medicine XVII; 112570Q (2020) https://doi.org/10.1117/12.2546868
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Harnessing the unprecedented spatiotemporal resolution capability of light to detect electrophysiological signals has been the goal of scientists for nearly 50 years. Advancements in this field could open new frontiers in neuroscience, cardiology and cellular biology. Yet, progress towards that goal remains elusive due to lack of electro-optic translators that can efficiently convert electrical activity to high photon-count optical signals. Here, we introduce an ultrasensitive and extremely bright nanoscale electric-field probe. Our electro-active plasmonic nanoantenna, offering ~3.25x10^3 times enhanced electric-field sensitivities than conventional plasmonic nanoantennas, overcomes the low sensitivity and photon-count limitations, and enables us to realize optical detection of electric-field dynamics with signal-to-shot-noise ratios (SSNR~ 60-220) from diffraction limited spots. We demonstrate label-free optical recording of field dynamics with sub-millisecond temporal resolution.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ahsan Habib, Xiangchao Zhu, Isik Uryan Can, Maverick McLanahan, Pinar Zorlutuna, and Ahmet A. Yanik "Label-free neurophotonics: electro-plasmonic biosensors for ultrasensitive detection of electrogenic activity of cells (Conference Presentation)", Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570Q (3 June 2020); https://doi.org/10.1117/12.2546868
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