Optical polarimetric elastography for biomechanical analysis

Andrea M. Armani; Kylie Trettner; Haijie Zuo; Katie Barajas; Raymond Yu; Alexa Hudnut

doi:10.1117/12.2543804

21 February 2020 Optical polarimetric elastography for biomechanical analysis

Andrea M. Armani, Kylie Trettner, Haijie Zuo, Katie Barajas, Raymond Yu, Alexa Hudnut

Proceedings Volume 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII; 1125805 (2020) https://doi.org/10.1117/12.2543804
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

To make transformative leaps in human health and wellness, our approach to healthcare must be reimagined. Researchers are pursuing multiple avenues, such as integrating health monitoring systems into wearable devices and leveraging machine learning methods to analyze health data. However, many of these approaches are pursued in isolation, and the resulting data is not cross correlated. By working directly with clinicians and clinician-researchers as well as bioinformaticians, we are identifying and addressing their critical needs. This presentation will discuss a recently developed instrument for measuring the elasticity of living tissue. Inspired by conventional mechanical compression testing, the portable instrument replaces the conventional pressure sensor with an array of optical fiber polarimetric sensors to improve both the resolution and sensitivity. These improvements allow the mechanical properties of unprocessed, living, resected tissue to be analyzed. To date, animal tissue samples (several organ systems and cartilage) have been measured. As a result of the improvement in resolution, micron-scale mechanical deformation behavior has been detected, in agreement with the tissue architecture. More complex investigations into the biomechanical properties of tumors (patient derived xenographs) are ongoing as well as improvements in the system design to accelerate data collection and analysis.

Conference Presentation

Citation Download Citation

Andrea M. Armani, Kylie Trettner, Haijie Zuo, Katie Barajas, Raymond Yu, and Alexa Hudnut "Optical polarimetric elastography for biomechanical analysis", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125805 (21 February 2020); https://doi.org/10.1117/12.2543804

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