Optimization of a plasmonic fluorescence biosensor platform to detect serum antibodies with high sensitivity and consistency (Conference Presentation)

Eunice Chou; Arturo Pilar; Ernest Guignon; William Page; George Gibson; Yi-Pin Lin; Nathaniel C. Cady

doi:10.1117/12.2551067

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10 March 2020 Optimization of a plasmonic fluorescence biosensor platform to detect serum antibodies with high sensitivity and consistency (Conference Presentation)

Eunice Chou, Arturo Pilar, Ernest Guignon, William Page, George Gibson, Yi-Pin Lin, Nathaniel C. Cady

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Proceedings Volume 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII; 1125806 (2020) https://doi.org/10.1117/12.2551067
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Detection of antibodies in the blood is an important clinical technique for diagnosing active infections and previous exposures. The grating-coupled fluorescent plasmonics (GC-FP) biosensing platform has been used to detect Lyme disease serum antibodies in patients and has been shown to be more sensitive than the current standard tests. In this study, we sought to design an affordable GC-FP detection system without sacrificing the sensitivity of data output. We further optimized our analysis strategies to achieve highly sensitive and consistent diagnostic results. This work ultimately aims to fill an unmet need for better detection of human Lyme disease.

Conference Presentation

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Eunice Chou, Arturo Pilar, Ernest Guignon, William Page, George Gibson, Yi-Pin Lin, and Nathaniel C. Cady "Optimization of a plasmonic fluorescence biosensor platform to detect serum antibodies with high sensitivity and consistency (Conference Presentation)", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125806 (10 March 2020); https://doi.org/10.1117/12.2551067

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