Use of peptide capture agents in porous silicon biosensors

Tengfei Cao; Rabeb Layouni; Matthew B. Coppock; Paul E. Laibinis; Sharon M. Weiss

doi:10.1117/12.2552932

21 February 2020 Use of peptide capture agents in porous silicon biosensors

Tengfei Cao, Rabeb Layouni, Matthew B. Coppock, Paul E. Laibinis, Sharon M. Weiss

Proceedings Volume 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII; 112580L (2020) https://doi.org/10.1117/12.2552932
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We report the use of a peptide-based capture agent as an alternative to antibodies and nucleic acid-based bioreceptors for porous silicon biosensors. Click chemistry is employed to attach azide-functionalized streptavidin-binding peptides to alkyne-modified porous silicon films. The attachment of the streptavidin-binding peptide and subsequent detection of streptavidin molecules are verified using optical reflectance and Fourier transform infrared spectroscopy measurements.

Citation Download Citation

Tengfei Cao, Rabeb Layouni, Matthew B. Coppock, Paul E. Laibinis, and Sharon M. Weiss "Use of peptide capture agents in porous silicon biosensors", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 112580L (21 February 2020); https://doi.org/10.1117/12.2552932

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