Control of cell arrangement on PMMA surface by femtosecond laser induced periodic nanostructures

N. Shinohara; M. Tsukamoto; Y. Sato

doi:10.1117/12.2545529

3 April 2020 Control of cell arrangement on PMMA surface by femtosecond laser induced periodic nanostructures

N. Shinohara, M. Tsukamoto, Y. Sato

Proceedings Volume 11268, Laser-based Micro- and Nanoprocessing XIV; 1126805 (2020) https://doi.org/10.1117/12.2545529
Event: SPIE LASE, 2020, San Francisco, California, United States

Abstract

We have experimentally shown that selective modification of the PMMA surface with a femtosecond laser irradiation could control the adhesion of cells to the PMMA surface. Using a femtosecond laser, periodic nanostructures were formed indirectly on a part of the PMMA film surface. By performing a cell cultivation test, the cell adhesion density to the substrate was measured. As a result, the cell adhesion density was 7 times higher in the laser processed area than in the non-processed area. This is considered to be due to the fact that the cell adhesive protein adheres well to the surface processed by the femtosecond laser.

Citation Download Citation

N. Shinohara, M. Tsukamoto, and Y. Sato "Control of cell arrangement on PMMA surface by femtosecond laser induced periodic nanostructures", Proc. SPIE 11268, Laser-based Micro- and Nanoprocessing XIV, 1126805 (3 April 2020); https://doi.org/10.1117/12.2545529

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