Development of a 3D carotid atlas for quantification of local volume change

Xueli Chen; Yuan Zhao; J. David Spence; Bernard Chiu

doi:10.1117/12.2549521

10 March 2020 Development of a 3D carotid atlas for quantification of local volume change

Xueli Chen, Yuan Zhao, J. David Spence, Bernard Chiu

Proceedings Volume 11313, Medical Imaging 2020: Image Processing; 113132R (2020) https://doi.org/10.1117/12.2549521
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Stroke is among the leading causes of death and disability throughout the world. Carotid atherosclerosis is a focal disease predominantly occurring at bifurcations, and for this reason, local progression/regression measurements of atherosclerosis allow for more sensitive detection of treatment effect than global measurements, such as total vessel wall volume (VWV). Vessel-wall-plus-plaque thickness (VWT) change has been developed to characterize local changes and has shown to be sensitive to treatment effect, but is unable to isolate changes in individual plaque components. In this work, we propose to quantify longitudinal voxel-by-voxel plaque-and-vessel-wall volume change (ΔVVol) and represent the ΔVVol distribution on a 3D standardized atlas. Such representation allows for quantitative comparison across patients and of the measurements obtained for the same patient at different time points. We introduced a 3D non-rigid registration framework to register the carotid ultrasound images acquired at baseline and a follow-up imaging session for each patient. A 3D volume equipped with voxel-by-voxel ΔVVol was obtained by taking the divergence of the displacement field obtained in non-rigid registration. This 3D volume was uniformly sampled in the vessel wall, and the ΔVVol distribution for each patient was represented in a 3D standardized map. The proposed 3D standardized ΔVVol map allows for the characterization of feature changes on a voxel-by-voxel basis that are masked in VWT quantification. This tool has the potential to further improve the sensitivity in treatment evaluation already attained by VWT quantification.

Citation Download Citation

Xueli Chen, Yuan Zhao, J. David Spence, and Bernard Chiu "Development of a 3D carotid atlas for quantification of local volume change", Proc. SPIE 11313, Medical Imaging 2020: Image Processing, 113132R (10 March 2020); https://doi.org/10.1117/12.2549521

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available