Deep convolutional neural networks for molecular subtyping of gliomas using magnetic resonance imaging

Dong Wei; Yiming Li; Yinyan Wang; Tianyi Qian; Yefeng Zheng

doi:10.1117/12.2544074

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16 March 2020 Deep convolutional neural networks for molecular subtyping of gliomas using magnetic resonance imaging

Dong Wei, Yiming Li, Yinyan Wang, Tianyi Qian, Yefeng Zheng

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Proceedings Volume 11314, Medical Imaging 2020: Computer-Aided Diagnosis; 113142M (2020) https://doi.org/10.1117/12.2544074
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Purpose: Knowledge of molecular subtypes of gliomas can provide valuable information for tailored therapies. This study aimed to investigate the use of deep convolutional neural networks (DCNNs) for noninvasive glioma subtyping with radiological imaging data according to the new taxonomy announced by the World Health Organization in 2016. Methods: A DCNN model was developed for the prediction of the five glioma subtypes based on a hierarchical classification paradigm. This model used three parallel, weight-sharing, deep residuallearning networks to process 2.5-dimensional input of trimodal MRI data, including T1-weighted, T1-weighted with contrast enhancement, and T2-weighted images. A data set comprising 1,016 real patients was collected for evaluation of the developed DCNN model. The predictive performance was evaluated via the area under the curve (AUC) from the receiver operating characteristic analysis. For comparison, the performance of a radiomicsbased approach was also evaluated. Results: The AUCs of the DCNN model for the four classification tasks in the hierarchical classification paradigm were 0.89, 0.89, 0.85, and 0.66, respectively, as compared to 0.85, 0.75, 0.67, and 0.59 of the radiomics approach. Conclusion: The results showed that the developed DCNN model can predict glioma subtypes with promising performance, given sufficient, non-ill-balanced training data.

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Dong Wei, Yiming Li, Yinyan Wang, Tianyi Qian, and Yefeng Zheng "Deep convolutional neural networks for molecular subtyping of gliomas using magnetic resonance imaging", Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis, 113142M (16 March 2020); https://doi.org/10.1117/12.2544074

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