3D microstructure analysis of human pulmonary emphysema using a synchrotron radiation CT

Kurumi Saito; Shota Fuketa; Ryouhei Shimatani; Yoshiki Kawata; Noboru Niki; Keiji Umetani; Yasutaka Nakano; Hiroaki Sakai; Toshihiro Okamoto; Harumi Itoh

doi:10.1117/12.2549441

28 February 2020 3D microstructure analysis of human pulmonary emphysema using a synchrotron radiation CT

Kurumi Saito, Shota Fuketa, Ryouhei Shimatani, Yoshiki Kawata, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hiroaki Sakai, Toshihiro Okamoto, Harumi Itoh

Author Affiliations +

Proceedings Volume 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging; 113170H (2020) https://doi.org/10.1117/12.2549441
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Progressive life-threatening lung disease is serious illness. Quantitative three-dimensional (3D) analysis of microstructure of human lung provides detailed information to understand the onset and progression of lung disease. We reported how to analyze normal structures of pulmonary lobule. This study is to elucidate 3D microstructures of emphysema. Two specimens of emphysema are examined using SRμCT. Compare 3D microstructures of bronchial and vasculature between emphysema and normal lungs. Eleven lung specimens were inflated and fixed using the Heitzman fixation method. These measurement experiments were performed at 20 or 25 keV X-ray energy on the SPring-8 beamline BL20B2. The reconstructed 3D image is about 13,370 x 13,370 x 4,900 voxels with an isotropic voxel size of 3μm. Vasculature and bronchi were extracted using a hierarchical algorithm with curvature analysis. The capillary bed and alveoli clusters of normal lung and emphysema were analyzed. In the case of emphysema, large alveoli clusters and thinner capillary beds were observed.

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Kurumi Saito, Shota Fuketa, Ryouhei Shimatani, Yoshiki Kawata, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hiroaki Sakai, Toshihiro Okamoto, and Harumi Itoh "3D microstructure analysis of human pulmonary emphysema using a synchrotron radiation CT", Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 113170H (28 February 2020); https://doi.org/10.1117/12.2549441

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