Translator Disclaimer
Presentation + Paper
2 March 2020 Use of 3D printed intracranial aneurysm phantoms to test the effect of flow diverters geometry on hemodynamics
Author Affiliations +
Abstract
Purpose: Intracranial aneurysm (IA) treatment using flow diverters (FDs) has become a widely used endovascular therapy with occlusion rates between 70 to 90 percent resulting in reduced mortality and morbidity. This significant variation in occlusion rates could be due to variations in patient anatomy, which causes different flow regimes in the IA dome. We propose to perform detailed in-vitro studies to observe the relation between the FD geometrical properties and IA hemodynamics changes. Materials and Methods: Idealized and patient-specific phantoms were 3D-printed, treated with FDs, and connected into a flow loop where intracranial hemodynamics were simulated using a programmable pump. Pressure measurements were acquired before and after treatment in the main arteries and IA domes for optimal and sub-optimal diameter sizing of the FD when compared with the main artery. The 3D-printed phantoms were scanned using a micro-CT to measure the ostium coverage, calculate the theoretical FD hydraulic resistance, and study its effect on flow. Results: The pressure differences between arteries and the IA dome for optimal FDs’ diameter with a hydraulic resistance of 3.4 were ~7 mmHg. When the FD was undersized, the hydraulic resistance was 4.2 and pressure difference increased to ~11 mmHg. Conclusion: 3D-printing allows development of very precise benchtop experiments where pressure sensors can be embedded in vascular phantoms to study hemodynamic changes due to various therapies such as IA treatment with FDs. In addition, precise imaging, such as micro-CT can be used in order to evaluate complex deployment geometries and study their correlation with flow.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ariana B. Allman, Mohammad Mahdi Shiraz Bhurwani, Jillian L. Senko, Ryan A. Rava, Alexander R. Podgorsak, Stephan Rudin, and Ciprian N. Ionita "Use of 3D printed intracranial aneurysm phantoms to test the effect of flow diverters geometry on hemodynamics", Proc. SPIE 11318, Medical Imaging 2020: Imaging Informatics for Healthcare, Research, and Applications, 1131803 (2 March 2020); https://doi.org/10.1117/12.2549575
PROCEEDINGS
12 PAGES + PRESENTATION

SHARE
Advertisement
Advertisement
Back to Top