High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)

Trevor Mitcham; Dmitry Nevozhay; Aaron Schwartz-Duval; Stephen Lai; Konstantin Sokolov; Richard Bouchard

doi:10.1117/12.2549324

27 March 2020 High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)

Trevor Mitcham, Dmitry Nevozhay, Aaron Schwartz-Duval, Stephen Lai, Konstantin Sokolov, Richard Bouchard

Author Affiliations +

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190Q (2020) https://doi.org/10.1117/12.2549324
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Current molecular imaging modalities face barriers to clinical implementation, providing a need for an improved clinical molecular imaging approach. We hypothesize that EGFR-targeted perfluorocarbon nanodroplets can label metastatic cells; they can then be activated (i.e., converted to a microbubble) and imaged using ultrasound in order to provide a molecular contrast agent that can inform treatment. Pulse sequences were developed for the Verasonics Vantage 128 system to activate and image dodecafluoropentane and dodecafluorohexane nanodroplets. Dodecafluoropentane nanodroplets provided 28-dB enhancement when imaged with pulse-inversion US in a tissue-mimicking environment, while dodecafluorohexane nanodroplets showed activation and subsequent recondensation, allowing for super-resolution imaging.

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Trevor Mitcham, Dmitry Nevozhay, Aaron Schwartz-Duval, Stephen Lai, Konstantin Sokolov, and Richard Bouchard "High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)", Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography, 113190Q (27 March 2020); https://doi.org/10.1117/12.2549324

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KEYWORDS

Nanodroplets

Ultrasonography

Imaging systems

Molecular imaging

Super resolution

Tissues

Visualization

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