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1 April 2020 Fabrication and characterization of step-index biocompatible and biodegradable polyesters based optical fiber
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Abstract
Biocompatible optical waveguides receive increasing attention owing to their application potential in the biomedical field. Our focus is on the fabrication and characterization of a new step-index biodegradable polymer optical fiber (bioPOF) using two commercial polyesters: poly(D,L-lactic-co-glycolic acid) (PDLGA) and poly(D,L-lactic acid) (PDLLA). Both polymers are regulated by US FDA, which allows projecting future clinical use of fibers made from these materials. We manufactured three preforms and we subsequently drew optical fibers with a standard heat-draw tower. We describe the chemical properties of the materials throughout the whole production chain from polymer granulates to preforms and then to optical fibers. We look into to the influence of the processing on the molecular weight and thermal characteristics of the polymers. Our step-index bioPOF with an outer diameter of 1000 ± 50 μm and a core of around 570 ±30 μm features record low attenuation of 0.26 dB∕cm at 950 nm for step index bioPOF, and a numerical aperture of 0.163. Immersion in phosphate-buffered saline (PBS) leads to hydrolytic degradation of the bioPOFs over a period of 3 months, accompanied with a 91% molecular weight loss. From the degradation study results, we anticipate that our bioPOFs can be used for biophotonic applications requiring deep tissue light delivery, such as photodynamic therapy.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Agnieszka Gierej, Adam Filipkowski, Dariusz Pysz, Ryszard Buczyński, Maxime Vagenende, Sandra Van Vlierberghe, Peter Dubruel, Hugo Thienpont, Thomas Geernaert, and Francis Berghmans "Fabrication and characterization of step-index biocompatible and biodegradable polyesters based optical fiber", Proc. SPIE 11355, Micro-Structured and Specialty Optical Fibres VI, 113550L (1 April 2020); https://doi.org/10.1117/12.2556161
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