Reconstructing complex force fields with optical tweezers

Laura Pérez-García; Alejandro V. Arzola; Giorgio Volpe; Giovanni Volpe

doi:10.1117/12.2568739

20 August 2020 Reconstructing complex force fields with optical tweezers

Laura Pérez-García, Alejandro V. Arzola, Giorgio Volpe, Giovanni Volpe

Proceedings Volume 11463, Optical Trapping and Optical Micromanipulation XVII; 114630K (2020) https://doi.org/10.1117/12.2568739
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

The methods used to measure force fields have not changed in the last 30 years; their disadvantages have limited the possibility of measuring nanoscopic forces in many potential applications, such as experiments with non-conservative force fields and out-of-equilibrium conditions. We propose a new powerful, simpler, robust, and faster algorithm to measure force fields, Force Reconstruction via Maximum-likelihood-estimator Analysis(FORMA). FORMA has allowed us to retrieve the conservative and non-conservative components of a force field acting on a Brownian particle from the analysis of its displacements, proving to have essential advantages over established techniques.

Conference Presentation

Citation Download Citation

Laura Pérez-García, Alejandro V. Arzola, Giorgio Volpe, and Giovanni Volpe "Reconstructing complex force fields with optical tweezers", Proc. SPIE 11463, Optical Trapping and Optical Micromanipulation XVII, 114630K (20 August 2020); https://doi.org/10.1117/12.2568739

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