Precision force measurements with optical tweezers

Declan Armstrong; Alexander Stilgoe; Timo Nieminen; Halina Rubinsztein-Dunlop

doi:10.1117/12.2571139

20 August 2020 Precision force measurements with optical tweezers

Declan Armstrong, Alexander Stilgoe, Timo Nieminen, Halina Rubinsztein-Dunlop

Proceedings Volume 11463, Optical Trapping and Optical Micromanipulation XVII; 114630L (2020) https://doi.org/10.1117/12.2571139
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

Piconewton scale forces can be measured with optical tweezers by monitoring the deflection of the trapping laser transmitted through a particle. This deflection is caused by a momentum transfer from the beam to the particle, measured as a change in voltage at a correctly placed position sensitive detector. To monitor these forces a conversion constant needs to be determined,which provides a mapping between units of voltage and Newtons. We propose, and experimentally verify, a new technique of detector calibration which outperforms previously developed methods. We also provide a quantitative comparison of different calibration techniques and the circumstances in which they are applicable.

Conference Presentation

Citation Download Citation

Declan Armstrong, Alexander Stilgoe, Timo Nieminen, and Halina Rubinsztein-Dunlop "Precision force measurements with optical tweezers", Proc. SPIE 11463, Optical Trapping and Optical Micromanipulation XVII, 114630L (20 August 2020); https://doi.org/10.1117/12.2571139

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