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20 August 2020 Micro and nano lasers from III-V semiconductors for intracellular sensing
Soraya Caixeiro, Alasdair H. Fikouras, Vera Titze, Andrea Di Falco, Marcel Schubert, Malte C. Gather
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Proceedings Volume 11468, Enhanced Spectroscopies and Nanoimaging 2020; 1146811 (2020) https://doi.org/10.1117/12.2568768
Event: SPIE Nanoscience + Engineering, 2020, Online Only
Abstract
Fluorescent probes are widely used in biological imaging; however, their spectral properties often limit sensing and multiplexing. Instead, intracellular lasers, offer increased spectral purity, photostability and distinct spectral outputs enabling the unique tagging of multiple cells over long time periods. Here we report on the optimisation of low threshold miniature lasers, 1000-fold smaller than the eukaryotic nucleus (Vlaser<0.1μm3). The improved fabrication method has allowed us to explore more complex laser geometries such as squares and pentagons, amongst others, to optimize the optical properties to the specific sensing or tracking application. Furthermore, we demonstrate intracellular sensing, by evaluating local cellular properties.
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Soraya Caixeiro, Alasdair H. Fikouras, Vera Titze, Andrea Di Falco, Marcel Schubert, and Malte C. Gather "Micro and nano lasers from III-V semiconductors for intracellular sensing", Proc. SPIE 11468, Enhanced Spectroscopies and Nanoimaging 2020, 1146811 (20 August 2020); https://doi.org/10.1117/12.2568768
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KEYWORDS
Group III-V semiconductors
Semiconductor lasers
Plasma etching
Biosensing
Dry etching
Electron beam lithography
Multiplexing
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