Ultra-sensitive and selective drug screening using frequency-locked microtoroid optical resonators

Judith Su

doi:10.1117/12.2569028

20 August 2020 Ultra-sensitive and selective drug screening using frequency-locked microtoroid optical resonators

Judith Su

Proceedings Volume 11468, Enhanced Spectroscopies and Nanoimaging 2020; 1146813 (2020) https://doi.org/10.1117/12.2569028
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

We use a microtoroid sensing platform known as FLOWER (frequency locked optical whispering evanescent resonator) to detect small molecule drug targets at attomolar concentrations. FLOWER combines whispering gallery mode optical resonator technology with frequency locking feedback control, balanced detection, and data-processing techniques. We have previously demonstrated label-free detection down to single macromolecules. To use FLOWER as a drug screening platform, we couple the high selectivity and detection capabilities of G-protein coupled receptors (GPCRs) for small ligands with FLOWER. We demonstrate detection of the peptide dynorphin A at attomolar concentrations using a microtoroid resonator coated with a lipid bilayer containing GPCRs.

Conference Presentation

Citation Download Citation

Judith Su "Ultra-sensitive and selective drug screening using frequency-locked microtoroid optical resonators", Proc. SPIE 11468, Enhanced Spectroscopies and Nanoimaging 2020, 1146813 (20 August 2020); https://doi.org/10.1117/12.2569028

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