Single molecule nanoscience: Role of fluctuation in function of biological molecular machine

Toshio Yanagida

doi:10.1117/12.2573002

22 August 2020 Single molecule nanoscience: Role of fluctuation in function of biological molecular machine

Toshio Yanagida

Proceedings Volume 11477, Molecular and Nano Machines III; 1147707 (2020) https://doi.org/10.1117/12.2573002
Event: SPIE Organic Photonics + Electronics, 2020, Online Only

Abstract

In 1995, we succeeded in observing a single molecule in an aqueous solution (Nature). In addition, we incorporated the technology of observing with precision of one nanometer and one ms, and measured the movement of molecular motor, myosin working in muscles in detail. We found that the myosin molecular motor moves by utilizing thermal fluctuation (Brownian motion). Computer simulation showed that the motion of myosin molecular motors utilizing thermal fluctuation successfully explains the flexible and adaptive mechanical properties of the muscle that they assemble.

Conference Presentation

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Toshio Yanagida "Single molecule nanoscience: Role of fluctuation in function of biological molecular machine", Proc. SPIE 11477, Molecular and Nano Machines III, 1147707 (22 August 2020); https://doi.org/10.1117/12.2573002

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