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12 October 2020 MACS: Rapid aqueous clearing system for three-dimensional mapping of intact organs
Dan Zhu
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Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 1155308 (2020) https://doi.org/10.1117/12.2573597
Event: SPIE/COS Photonics Asia, 2020, Online Only
Abstract
Tissue optical clearing techniques have provided important tools for large-volume imaging. Here, m-xylylenediamine (MXDA) is firstly introduced into tissue clearing and used to develop a rapid, highly efficient aqueous clearing method with robust lipophilic dyes compatibility, termed MXDA-based Aqueous Clearing System (MACS). MACS can render whole adult brains highly transparent within 2.5 d and is also applicable for other intact organs. Meanwhile, MACS possesses ideal compatibility with multiple probes, especially for lipophilic dyes. MACS achieves three-dimensional (3D) imaging of the intact neural structures.
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Dan Zhu "MACS: Rapid aqueous clearing system for three-dimensional mapping of intact organs", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 1155308 (12 October 2020); https://doi.org/10.1117/12.2573597
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KEYWORDS
3D image processing
Brain
Kidney
Luminescence
Optical clearing
Pathology
Stereoscopy
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