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10 October 2020 High-speed super-resolution imaging of intracellular organelle interactions
Dong Li
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Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 1155311 (2020) https://doi.org/10.1117/12.2574701
Event: SPIE/COS Photonics Asia, 2020, Online Only
Abstract
In eukaryotic cell, various organelles and cytoskeletons are very dynamic, yet highly organized to orchestrate complex cellular functions. Visualizing these interactions requires noninvasive, long duration imaging of the intracellular environment at high spatial and temporal resolution. However, the tradeoffs between spatial and temporal resolution, and low phototoxicity/photobleaching in current super-resolution imaging techniques prevent biologists from accurately characterizing these dynamic processes. To achieve these normally opposing goals, in this talk I will discuss our latest developments in grazing incidence structured illumination microscopy (GI-SIM), and lattice light sheet microscopy (LLSM).
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Dong Li "High-speed super-resolution imaging of intracellular organelle interactions", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 1155311 (10 October 2020); https://doi.org/10.1117/12.2574701
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KEYWORDS
Super resolution
Image resolution
Biological research
Cell biology
Grazing incidence
Microscopy
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