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15 February 2021 Preclinical in vivo x-ray fluorescence computed tomography
Kian Shaker, Carmen Vogt, Yurika Katsu-Jimenéz, Raoul V. Kuiper, Kenth Andersson, Yuyang Li, Jakob C. Larsson, Aida Rodriguez-Garcia, Muhammet S. Toprak, Marie Arsenian-Henriksson, Hans M. Hertz
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Proceedings Volume 11595, Medical Imaging 2021: Physics of Medical Imaging; 115951O (2021) https://doi.org/10.1117/12.2580858
Event: SPIE Medical Imaging, 2021, Online Only
Abstract
X-ray fluorescence computed tomography (XFCT) with nanoparticles (NPs) as contrast agents has reached technical maturity allowing for in vivo preclinical imaging in the laboratory setting. We present the first in vivo longitudinal study with XFCT where mice were 5 times each during an 8-week period. Imaging is performed with low radiation dose (<25 mGy) and high signal-to-background for high-spatial-resolution imaging (200-400 µm) of molybdenum NP accumulations (down to ~50 µg/ml Mo). We further discuss our ongoing development of protein-coated NPs for actively targeting molecular markers (e.g., cancer), as well as potential clinical applications.
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Kian Shaker, Carmen Vogt, Yurika Katsu-Jimenéz, Raoul V. Kuiper, Kenth Andersson, Yuyang Li, Jakob C. Larsson, Aida Rodriguez-Garcia, Muhammet S. Toprak, Marie Arsenian-Henriksson, and Hans M. Hertz "Preclinical in vivo x-ray fluorescence computed tomography", Proc. SPIE 11595, Medical Imaging 2021: Physics of Medical Imaging, 115951O (15 February 2021); https://doi.org/10.1117/12.2580858
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KEYWORDS
Nanoparticles
X-ray fluorescence spectroscopy
Computed tomography
In vivo imaging
Gold
Molybdenum
Fluorescence tomography
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