Quantitative assessment of proton beam dose and myocardial lesion formation detected by high-resolution, ex vivo delayed contrast-enhanced MRI for treatment of ventricular tachycardia

M. E. Rettmann; A. Suzuki; A. J. Deisher; S. Hohmann; K. Imamura; J. Dickow; H. Konishi; S. Wang; L. K. Newman; K. Parker; K. Monahan; J. J. Kruse; K. Merrell; R. Foote; M. G. Herman; D. L. Packer

doi:10.1117/12.2582220

15 February 2021 Quantitative assessment of proton beam dose and myocardial lesion formation detected by high-resolution, ex vivo delayed contrast-enhanced MRI for treatment of ventricular tachycardia

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Hohmann, K. Imamura, J. Dickow, H. Konishi, S. Wang, L. K. Newman, K. Parker, K. Monahan, J. J. Kruse, K. Merrell, R. Foote, M. G. Herman, D. L. Packer

Author Affiliations +

Proceedings Volume 11598, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling; 115980G (2021) https://doi.org/10.1117/12.2582220
Event: SPIE Medical Imaging, 2021, Online Only

Abstract

Proton beam therapy has the potential to non-invasively treat ventricular tachycardia (VT) by homogenizing infarct scar. It has been previously demonstrated that proton beam therapy can create lesions in healthy myocardial tissue, thereby suggesting a potential for treatment of VT. In prior work, we quantified the relationship between dose delivered to myocardial tissue with lesion formation identified with in vivo, delayed contrast-enhanced magnetic resonance imaging (DCE-MRI) scans. In the current work, we evaluate the relationship of delivered dose with lesions identified in high resolution, post-mortem DCE-MRI scans. Deformable registration is used to align the dose maps from the baseline planning CT scans to ex vivo scans following proton beam therapy in swine. The current study demonstrates that nearly 100% of tissue exposed to a dose of 30 Gy or higher developed into lesion and approximately 85% of the tissue in the 20-30 Gy interval developed into lesion. On the other hand, tissue exposed to doses of 10 Gy or less tended to remain healthy myocardium, with less than 10% of tissue in the 5-10 Gy range and almost no tissue in the 0-5 Gy range developing into lesion.

Conference Presentation

Citation Download Citation

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Hohmann, K. Imamura, J. Dickow, H. Konishi, S. Wang, L. K. Newman, K. Parker, K. Monahan, J. J. Kruse, K. Merrell, R. Foote, M. G. Herman, and D. L. Packer "Quantitative assessment of proton beam dose and myocardial lesion formation detected by high-resolution, ex vivo delayed contrast-enhanced MRI for treatment of ventricular tachycardia", Proc. SPIE 11598, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling, 115980G (15 February 2021); https://doi.org/10.1117/12.2582220

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE