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5 March 2021 Correlation of ex-vivo focal laser ablation treatment of human prostate and porcine liver with MR imaging and histopathology: understanding the ablation zone
Luigi A. van Riel M.D., Rob van Kollenburg M.D., Jorg Oddens M.D., Theo de Reijke M.D., Ton van Leeuwen, Martijn de Bruin
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Proceedings Volume 11619, Advanced Photonics in Urology; 1161904 (2021) https://doi.org/10.1117/12.2580353
Event: SPIE BiOS, 2021, Online Only
Abstract
Transperineal laser ablation (TPLA) treatment of prostate cancer allows for a minimal invasive treatment approach. However, understanding of the ablation zone development and the 3D size are crucial for accurate treatment of prostate cancer. Therefore, we developed an ex-vivo experimental focal laser ablation set-up using a 1064nm CW diode laser to simulate a TPLA treatment, using human prostate and porcine liver. We quantitatively evaluated the thermal distribution and ablation zone volume on high-resolution MR imaging and histopathology to determine the 3D size of the ablation zone. These results allow for development of a dosimetry model of clinical TPLA treatments.
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Luigi A. van Riel M.D., Rob van Kollenburg M.D., Jorg Oddens M.D., Theo de Reijke M.D., Ton van Leeuwen, and Martijn de Bruin "Correlation of ex-vivo focal laser ablation treatment of human prostate and porcine liver with MR imaging and histopathology: understanding the ablation zone", Proc. SPIE 11619, Advanced Photonics in Urology, 1161904 (5 March 2021); https://doi.org/10.1117/12.2580353
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KEYWORDS
Laser ablation
Prostate
Magnetic resonance imaging
Liver
Fiber lasers
Light emitting diodes
Prostate cancer
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