Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination

Martin Ahrens; Christian Idel; Peter König; Gereon Hüttmann; Hinnerk Schulz-Hildebrandt

doi:10.1117/12.2578787

5 March 2021 Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination

Martin Ahrens, Christian Idel, Peter König, Gereon Hüttmann, Hinnerk Schulz-Hildebrandt

Proceedings Volume 11620, Endoscopic Microscopy XVI; 1162008 (2021) https://doi.org/10.1117/12.2578787
Event: SPIE BiOS, 2021, Online Only

Abstract

We present an endomicroscopic OCT probe for in vivo examination of the mucosa in the nose based on a voice coil actuator. The side-viewing endoscope has a tip diameter of 3 mm and a usable length of 7 cm. A graded-index (GRIN) lens optics achieve a lateral resolution of 3 µm. At an actuator frequency between 40 Hz and 100 Hz the scanning range is up to 2 mm. A supercontinuum laser based mOCT system enables an axial resolution of 1 µm at a depth range of 700 µm. The postprocessing includes the linearization of the sinusoidal scan pattern and a registration of the time series from B-scans. The potential of the new design was demonstrated on ex-vivo mouse trachea. Essential morphological structures such as epithelium with ciliated cells, glands, blood and lymph vessels and also mucus transport were be visualized.

Conference Presentation

Citation Download Citation

Martin Ahrens, Christian Idel, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt "Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination", Proc. SPIE 11620, Endoscopic Microscopy XVI, 1162008 (5 March 2021); https://doi.org/10.1117/12.2578787

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available