In vivo microscopic imaging for diagnosis of fibrotic interstitial lung disease using endobronchial optical coherence tomography

Sreyankar Nandy; Rebecca A. Israel; Ashok Muniappan; Angela Shih; Benjamin W. Roop; Amita Sharma; Colleen M. Keyes; Thomas V. Colby; Hugh G. Auchincloss; Henning A. Gaissert; Michael Lanuti; Christopher R. Morse; Harald C. Ott; John C. Wain; Cameron D. Wright; Mari Mino-Kenudson; Nora K. Horick; Diane L. Davies; Lloyd Liang; David C. Adams; Margit V. Szabari; Peter Caravan; Benjamin D. Medoff; Melissa J. Suter; Lida P. Hariri

doi:10.1117/12.2578667

5 March 2021 In vivo microscopic imaging for diagnosis of fibrotic interstitial lung disease using endobronchial optical coherence tomography

Sreyankar Nandy, Rebecca A. Israel, Ashok Muniappan, Angela Shih, Benjamin W. Roop, Amita Sharma, Colleen M. Keyes, Thomas V. Colby, Hugh G. Auchincloss, Henning A. Gaissert, Michael Lanuti, Christopher R. Morse, Harald C. Ott, John C. Wain, Cameron D. Wright, Mari Mino-Kenudson, Nora K. Horick, Diane L. Davies, Lloyd Liang, David C. Adams, Margit V. Szabari, Peter Caravan, Benjamin D. Medoff, Melissa J. Suter, Lida P. Hariri

Author Affiliations +

Proceedings Volume 11620, Endoscopic Microscopy XVI; 116200A (2021) https://doi.org/10.1117/12.2578667
Event: SPIE BiOS, 2021, Online Only

Abstract

Early, accurate diagnosis of interstitial lung disease (ILD) is critical for clinical management and therapeutic decision-making, especially distinguishing idiopathic pulmonary fibrosis (IPF) from non-IPF ILD. Unfortunately, current diagnostic imaging methods are limited in resolution and surgical biopsy methods are invasive. In this study, we evaluate the accuracy of endobronchial optical coherence tomography (EB-OCT) as a low-risk method for in vivo ILD diagnosis in patients undergoing surgical biopsy. EB-OCT was able to distinguish diagnostic microanatomical features of IPF from non-IPF ILDs, independently compared against surgical biopsy. These findings support the potential of OCT as a minimally-invasive method for IPF diagnosis.

Conference Presentation

Citation Download Citation

Sreyankar Nandy, Rebecca A. Israel, Ashok Muniappan, Angela Shih, Benjamin W. Roop, Amita Sharma, Colleen M. Keyes, Thomas V. Colby, Hugh G. Auchincloss, Henning A. Gaissert, Michael Lanuti, Christopher R. Morse, Harald C. Ott, John C. Wain, Cameron D. Wright, Mari Mino-Kenudson, Nora K. Horick, Diane L. Davies, Lloyd Liang, David C. Adams, Margit V. Szabari, Peter Caravan, Benjamin D. Medoff, Melissa J. Suter, and Lida P. Hariri "In vivo microscopic imaging for diagnosis of fibrotic interstitial lung disease using endobronchial optical coherence tomography", Proc. SPIE 11620, Endoscopic Microscopy XVI, 116200A (5 March 2021); https://doi.org/10.1117/12.2578667

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available