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5 March 2021 Diffuse reflectance spectroscopy to study the effects of radiation therapy dose on tumor microenvironment
April Jules, Davin Means, Joel Rodriguez Troncoso, Sina Dadgar, Narasimhan Rajaram
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Proceedings Volume 11622, Multiscale Imaging and Spectroscopy II; 116220A (2021) https://doi.org/10.1117/12.2577875
Event: SPIE BiOS, 2021, Online Only
Abstract
We used diffuse reflectance spectroscopy to assess the effects of different radiation therapy doses on tumor microenvironment. We injected 4T1 cells into the flanks of 25 mice to develop tumor xenografts, and randomly distributed the animals into control and radiation groups, which received a dose of either 1, 2, or 4 Gy. Treatment started when tumors reached a volume of 200 mm3. DRS measurements were obtained prior to and 1 hour after radiation on the five days of treatment, and once a day thereafter. Our data demonstrates that DRS is sensitive to tumor microenvironmental changes after low doses of radiation.
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April Jules, Davin Means, Joel Rodriguez Troncoso, Sina Dadgar, and Narasimhan Rajaram "Diffuse reflectance spectroscopy to study the effects of radiation therapy dose on tumor microenvironment", Proc. SPIE 11622, Multiscale Imaging and Spectroscopy II, 116220A (5 March 2021); https://doi.org/10.1117/12.2577875
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KEYWORDS
Tumors
Radiation effects
Radiotherapy
Diffuse reflectance spectroscopy
Cancer
Oncology
Optical testing
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