Merging light and sound for noninvasive interrogation and modulation of the mammalian brain across scales

Hector Estrada; Justine Robin; Ali Özbek; Shy Shoham; Daniel Razansky

doi:10.1117/12.2590880

5 March 2021 Merging light and sound for noninvasive interrogation and modulation of the mammalian brain across scales

Hector Estrada, Justine Robin, Ali Özbek, Shy Shoham, Daniel Razansky

Proceedings Volume 11622, Multiscale Imaging and Spectroscopy II; 116220O (2021) https://doi.org/10.1117/12.2590880
Event: SPIE BiOS, 2021, Online Only

Abstract

Light- and ultrasound-based technologies are growingly used for brain interrogation and modulation of neural activity at various spatial and temporal scales. We recently developed functional optoacoustic neuro-tomography (FONT) technique to enable the recording of multiple hemodynamic parameters at high spatial resolution across the entire mouse brain. The method was also applied for tracking rapid neural dynamics using genetically encoded calcium indicators, thus overcoming the longstanding penetration barrier of optical microscopy in scattering brains. FONT thus enables large-scale neural recording at penetration depths and spatio-temporal resolution scales not covered with the existing micro- and macro-scopic functional neuroimaging techniques. Hybrid implementations have further been developed to allow for real-time monitoring of the effects of transcranial ultrasound stimulation of the living brain.

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Citation Download Citation

Hector Estrada, Justine Robin, Ali Özbek, Shy Shoham, and Daniel Razansky "Merging light and sound for noninvasive interrogation and modulation of the mammalian brain across scales", Proc. SPIE 11622, Multiscale Imaging and Spectroscopy II, 116220O (5 March 2021); https://doi.org/10.1117/12.2590880

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