Ultrafast adaptive optics for imaging the living human retina

Yan Liu; James A. Crowell; Kazuhiro Kurokawa; Ayoub Lassoued; Hae Won Jung; Marcel T. Bernucci; Donald T. Miller

doi:10.1117/12.2578701

5 March 2021 Ultrafast adaptive optics for imaging the living human retina

Yan Liu, James A. Crowell, Kazuhiro Kurokawa, Ayoub Lassoued, Hae Won Jung, Marcel T. Bernucci, Donald T. Miller

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 1162307 (2021) https://doi.org/10.1117/12.2578701
Event: SPIE BiOS, 2021, Online Only

Abstract

Adaptive optics (AO) enables retinal imaging at cellular resolution. Today, most ophthalmic AO systems have closed-loop bandwidths of ≤2 Hz, insufficient for many conditions encountered in the clinic. Here, we develop an ultrafast AO with a bandwidth of 32.6 Hz and evaluate its use with optical coherence tomography. After AO activation, the RMS wavefront aberration from an un-cyclopleged human eye dropped below diffraction limit within 5 ms, 40× faster than the fastest ophthalmic AO system reported in the literature. Because the system converges so quickly, we can use the data immediately after a blink or when imaging locations are changed, even in eyes wearing contact lenses.

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Yan Liu, James A. Crowell, Kazuhiro Kurokawa, Ayoub Lassoued, Hae Won Jung, Marcel T. Bernucci, and Donald T. Miller "Ultrafast adaptive optics for imaging the living human retina", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 1162307 (5 March 2021); https://doi.org/10.1117/12.2578701

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KEYWORDS

Adaptive optics

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