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5 March 2021 Protection of corneal epithelium by repetitive magnetic stimulation in a rabbit model of dry eye
Ygal Rotenstreich M.D., Adi Tzameret, Zehavit Goldberg, Ettel Bubis, Noa Avni-Zauberman M.D., Ofra Kalter-Leibovici, Arie L. Marcovich M.D., Guy Ben Simon M.D., Ifat Sher
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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230Q (2021) https://doi.org/10.1117/12.2583382
Event: SPIE BiOS, 2021, Online Only
Abstract
In this preclinical study we demonstrated that treatment with repetitive magnetic stimulation (RMS) protects the epithelial layer in a rabbit model of exposure keratopathy, preventing loss of the epithelial cells and maintaining the function of the corneal barrier under extreme desiccation conditions. A single 15 minutes RMS treatment supported corneal barrier integrity under acute desiccation for 3 months. AS-OCT imaging and histopathology analysis demonstrated the safety of RMS treatment. Our study suggests that repetitive magnetic stimulation may present a novel treatment for protection of corneal epithelium in patients with DES, and may alleviate DES symptoms.
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Ygal Rotenstreich M.D., Adi Tzameret, Zehavit Goldberg, Ettel Bubis, Noa Avni-Zauberman M.D., Ofra Kalter-Leibovici, Arie L. Marcovich M.D., Guy Ben Simon M.D., and Ifat Sher "Protection of corneal epithelium by repetitive magnetic stimulation in a rabbit model of dry eye", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230Q (5 March 2021); https://doi.org/10.1117/12.2583382
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KEYWORDS
Eye
Eye models
Magnetism
Optical coherence tomography
Fluorometers
Proteins
Safety
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