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5 March 2021 Dual-mode endoscopic system combining OCT and autofluorescence imaging for inner ear hearing loss diagnosis and therapy guidance
Jesung Park, Tao Cheng, Daniel Lee, Gopi Maguluri, John Grimble, Nick Iftimia
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Proceedings Volume 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology; 1162705 (2021) https://doi.org/10.1117/12.2582611
Event: SPIE BiOS, 2021, Online Only
Abstract
Sensorineural hearing loss (SNHL) is the most common sensory problem that causes permanent hearing loss due to the damage of cochlear hair cells. Current clinical imaging techniques do not provide sufficient resolution and functional assessment of the intracochlear structures. We developed a dual-mode endoscopic system that combines optical coherence tomography and autofluorescence to visualize the morphology and biochemical changes of the intracochlear structures. The preclinical assessment of the system was performed in a ovine model of SNHL in vivo. The preliminary results suggest that this approach may provide more accurate diagnosis of cochlear pathology and enable targeted SNHL therapies.
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Jesung Park, Tao Cheng, Daniel Lee, Gopi Maguluri, John Grimble, and Nick Iftimia "Dual-mode endoscopic system combining OCT and autofluorescence imaging for inner ear hearing loss diagnosis and therapy guidance", Proc. SPIE 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology, 1162705 (5 March 2021); https://doi.org/10.1117/12.2582611
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KEYWORDS
Endoscopy
Ear
Optical coherence tomography
Auto-fluorescence imaging
Imaging systems
Animal model studies
Bone
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