Maintenance of cerebral blood flow (CBF) is required for normal brain function. Yet, measuring CBF in adult humans requires high-end medical instrumentation. Here, leveraging two-dimensional (2D) complementary metal-oxide-semiconductor (CMOS) technology, we present and validate an optical approach, called multi-exposure interferometric Diffusing Wave Spectroscopy (MiDWS), to monitor blood flow index (BFI), a proxy for CBF, via the adult human forehead. MiDWS employs interferometry to detect low light levels, and probes the optical field autocorrelation by varying the sensor exposure time. This approach may enable human brain optical BFI monitoring with 2D CMOS sensors, with associated economies of scale.
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