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5 March 2021 3D printing fluorescent material with tunable optical properties for biomedical optics phantoms using photo-curable resins
Alberto J. Ruiz, Sadhya Garg, Mia K. Giallorenzi, Ethan P. M. LaRochelle, Kimberley S Samkoe, Brian W. Pogue
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Proceedings Volume 11633, Design and Quality for Biomedical Technologies XIV; 116330A (2021) https://doi.org/10.1117/12.2583350
Event: SPIE BiOS, 2021, Online Only
Abstract
Fluorescence imaging for surgical guidance is a proven modality that allows for visualization of fluorescent markers in numerous biological imaging applications. As the field continues to develop there is an urgent need for fluorescence-imaging standards and targets that enable system characterization, performance monitoring, and the development of analytical algorithms. 3D-printing technology has shown promise in providing biomimicking phantoms that allow simulation of realistic clinical conditions. Here, we present a comprehensive method for 3D printing fluorescent and tissue-equivalent material using photo-curable resins. We show the ability to print Indocyanine-green (ICG) equivalent material in complex shapes that would enable the evaluation of ICG-specific clinical systems. The method presented allows tuning of both the reduced scattering and absorption coefficients at multiple wavelengths, allowing for application-specific manufacturing of 3D-printed phantoms.
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Alberto J. Ruiz, Sadhya Garg, Mia K. Giallorenzi, Ethan P. M. LaRochelle, Kimberley S Samkoe, and Brian W. Pogue "3D printing fluorescent material with tunable optical properties for biomedical optics phantoms using photo-curable resins", Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 116330A (5 March 2021); https://doi.org/10.1117/12.2583350
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KEYWORDS
3D printing
Tissue optics
Biomedical optics
Algorithm development
Standards development
Luminescence
Manufacturing
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