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5 March 2021 3D glass nanofluidics fabricated by femtosecond laser processing for study on cancer cell metastasis
Koji Sugioka, Felix Sima
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Proceedings Volume 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX; 116370T (2021) https://doi.org/10.1117/12.2590777
Event: SPIE BiOS, 2021, Online Only
Abstract
We have developed hybrid femtosecond laser processing for fabrication of 3D microfluidic SERS chips. The resulting chip can perform the real-time SERS detection of Cd2+ ions at concentrations as low as 10 ppb. We have further proposed a novel strategy by taking advantage of the microfluidic configuration. The microfluidic chip can produce an interface of analyte solution and air on the SERS substrate in the microfluidic channel, which locally aggregates the analyte molecules at the interface during the measurements (LI-SERS). The LI-SERS technique achieves the analytical enhancement factor reaching 1.5 × 10^14 with a detection limit below 10 aM.
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Koji Sugioka and Felix Sima "3D glass nanofluidics fabricated by femtosecond laser processing for study on cancer cell metastasis", Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370T (5 March 2021); https://doi.org/10.1117/12.2590777
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KEYWORDS
Microfluidics
Femtosecond phenomena
3D surface sensing
Interfaces
Silver
Plating
Rhodamine
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