A toolbox for the comprehensive, real-time optimization of plasmonic photothermal therapy demonstrated on an orthotopic renal tumor model

Pablo R. Fernández Esteberena; Clara Vilches; María del Mar Martínez Lozano; Ignacio de Miguel; Oriol Casanovas; Romain Quidant; Turgut Durduran

doi:10.1117/12.2577762

5 March 2021 A toolbox for the comprehensive, real-time optimization of plasmonic photothermal therapy demonstrated on an orthotopic renal tumor model

Pablo R. Fernández Esteberena, Clara Vilches, María del Mar Martínez Lozano, Ignacio de Miguel, Oriol Casanovas, Romain Quidant, Turgut Durduran

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163910 (2021) https://doi.org/10.1117/12.2577762
Event: SPIE BiOS, 2021, Online Only

Abstract

Plasmonic photothermal therapy is an emerging complementary method for treating tumors usually studied pre-clinically in mice with small subcutaneous tumors. In this project, it is conducted on a more realistic orthotopic xenograft renal carcinoma mouse model, while tissue optical properties are monitored non-invasively by diffuse optics. Hybrid diffuse reflectance spectroscopy and diffuse correlation spectroscopy are used to quantify tissue hemodynamics, the accumulated plasmonic nanoparticle concentration and therapy induced physiological changes. The results show the need for personalization and the predictive capabilities of the monitoring, which, in turn, would allow for therapy optimization.

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Pablo R. Fernández Esteberena, Clara Vilches, María del Mar Martínez Lozano, Ignacio de Miguel, Oriol Casanovas, Romain Quidant, and Turgut Durduran "A toolbox for the comprehensive, real-time optimization of plasmonic photothermal therapy demonstrated on an orthotopic renal tumor model", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163910 (5 March 2021); https://doi.org/10.1117/12.2577762

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