In vivo time-domain diffuse correlation spectroscopy at 1 μm

L. Colombo; M. Pagliazzi; S. Konugolu-Venkata-Sekar; D. Contini; T. Durduran; A. Pifferi

doi:10.1117/12.2578443

5 March 2021 In vivo time-domain diffuse correlation spectroscopy at 1 μm

L. Colombo, M. Pagliazzi, S. Konugolu-Venkata-Sekar, D. Contini, T. Durduran, A. Pifferi

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163911 (2021) https://doi.org/10.1117/12.2578443
Event: SPIE BiOS, 2021, Online Only

Abstract

Diffuse correlation spectroscopy (DCS) is an optical technique which, by studying the speckle intensity fluctuations of coherent light diffused in a turbid medium, retrieves information regarding the scatterers motion. In the case of biological tissues, the particles of interest are the red blood cells, from which is possible to measure non-invasively microvascular blood flow (BF). However, being based on a continuous-wave light source, depth discrimination is achievable only by using multiple source-detector separations. On the other hand, time-domain (TD) DCS is a novel approach which exploits a pulsed yet coherent light source to discriminate the intensity fluctuations at different photon time-of-flights. This additional information is beneficial for in vivo applications, due to the physical relationship between photon time-of-flight and mean depth penetration. TD-DCS is typically performed in the spectral range between 700 and 800 nm. Here, we explore TD-DCS in a new spectral range compared to the typical one, moving to the spectral region beyond the water absorption peak (i.e., >970 nm). We performed liquid phantom and in vivo experiments on the human muscle at a wavelength of 1000 nm. Also, the possible advantages in terms of depth sensitivity and signal-to-noise ratio are discussed.

Conference Presentation

Citation Download Citation

L. Colombo, M. Pagliazzi, S. Konugolu-Venkata-Sekar, D. Contini, T. Durduran, and A. Pifferi "In vivo time-domain diffuse correlation spectroscopy at 1 μm", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163911 (5 March 2021); https://doi.org/10.1117/12.2578443

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