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5 March 2021 Spatial frequency domain imaging for treatment assessment in a mouse femoral injury model
Jingxuan Ren, Ashley R. Proctor, Danielle Benoit, Regine Choe
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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391E (2021) https://doi.org/10.1117/12.2578988
Event: SPIE BiOS, 2021, Online Only
Abstract
The feasibility of the spatial frequency domain imaging (SFDI) for early treatment assessment in a mouse femoral injury model was investigated. For mice with and without treatment, the revascularization process was monitored by SFDI, which provides the total hemoglobin concentration (THC) of the injured bone and surrounding soft tissues. The biomechanical strength of the healed femurs was measured after 4 weeks of healing. The correlation between the SFDI-derived THC and the biomechanical strength will be investigated. Such correlation will be used to develop a prediction model to estimate the bone healing outcome at an early time point.
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Jingxuan Ren, Ashley R. Proctor, Danielle Benoit, and Regine Choe "Spatial frequency domain imaging for treatment assessment in a mouse femoral injury model", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391E (5 March 2021); https://doi.org/10.1117/12.2578988
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KEYWORDS
Injuries
Bone
Blood
Hemodynamics
In vivo imaging
Molecules
Nanoparticles
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