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5 March 2021 Quantification of path-length-resolved blood flow changes of human tissue by time-domain diffuse correlation spectroscopy (TD-DCS)
Saeed Samaei, Piotr Sawosz, Michal Kacprzak, Dawid Borycki, Adam Liebert
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Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410Q (2021) https://doi.org/10.1117/12.2583076
Event: SPIE BiOS, 2021, Online Only
Abstract
We utilized time-domain diffuse correlation spectroscopy (TD-DCS) to quantify depth-resolved blood flow changes for in vivo experiments on arm and forehead adult humans. We illustrated that conventional TD-DCS processing is incapable of estimating blood flow changes at short source-detector separations, as expected. To tackle this problem, we introduced a novel model. We recovered the relative blood flow index of the forearm muscle during the cuff occlusion challenge and human forehead under variable pressure accurately.
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Saeed Samaei, Piotr Sawosz, Michal Kacprzak, Dawid Borycki, and Adam Liebert "Quantification of path-length-resolved blood flow changes of human tissue by time-domain diffuse correlation spectroscopy (TD-DCS)", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410Q (5 March 2021); https://doi.org/10.1117/12.2583076
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KEYWORDS
Blood circulation
Tissue optics
Spectroscopy
Laser scattering
Laser sources
Light scattering
Optical testing
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