A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan; Chih-Hao Liu; Manmohan Singh; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2583340

5 March 2021 A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan, Chih-Hao Liu, Manmohan Singh, Rajesh C. Miranda, Kirill V. Larin

Author Affiliations +

Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 1164109 (2021) https://doi.org/10.1117/12.2583340
Event: SPIE BiOS, 2021, Online Only

Abstract

Prenatal alcohol exposure (PAE) causes a spectrum of abnormalities, collectively termed as fetal alcohol spectrum disorders (FASD). The severity of the defect depends on the amount of alcohol consumed and the period of gestation during which alcohol was consumed. PAE during the second trimester is known to affect fetal brain development as this period of gestation marks the peak period for fetal neurogenesis and angiogenesis. Our previous study evaluated acute changes in fetal brain vasculature after PAE. However, not much has been done to assess concurrent changes on both the fetal and maternal side. This study uses correlation mapping optical coherence angiography (cm-OCA) to evaluate changes in vasculature in the fetal brain and the maternal hindlimb after maternal exposure to alcohol. Results showed drastic vasoconstriction in the fetal brain while vasodilation was seen in the mother, unlike results from the sham group, where there was no significant change in both the fetus and the mother. Changes seen in the fetal brain was similar to our previously published results.

Conference Presentation

Citation Download Citation

Raksha Raghunathan, Chih-Hao Liu, Manmohan Singh, Rajesh C. Miranda, and Kirill V. Larin "A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 1164109 (5 March 2021); https://doi.org/10.1117/12.2583340

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available